DOR does suck, but you can still be successful! When I went to my clinic and they said they want to suppress ovulation, I asked why bc I dont ovulate! I felt icky too the first day of starting estrace but I think it's also because they put me on a zpac to kill any infections and that made me sick my fingers are crossed that your period doesn't come and you can start cycling. By clicking sign up, you agree to receive emails from FertilitySmarts and agree to our Terms of Use and Privacy Policy. Typically, you also add other stims once you start your cycle, too (Menopur, GonalF), so those could be in high doses. I understand why they want to suppress ovulation but it just doesn't seem like a good idea in someone over 40? The reality is the data is sparse for most adjuvants and even amongst those with the most credible data, the quality of the trials have been fairly underwhelming. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. They put me on birth control pills for a month and are skipping the early stage Estrace this time around. They monitor the follicle size and u do the trigger still so the know when to retrieve. 2 expanded blasts on Day 6 were not biospied. Is a micro-dose lupron protocol considered a low-dose protocol? A fundamental question is whether protocols using a lower dose of gonadotropins do as well as those using a higher dose of gonadotropins. The misoprostol was not expensive; on average, it's about $30. As a result, the Antagonist strategy is generally preferred for women at especially high risk of developing OHSS, namely women with PCOS, younger women, women with high AMH or AFCs, African American women, and those who produced a high number of eggs in a recent cycle. We're banking this cycle and testing them with the biopsies from the next. Thanks! Estrogen Priming is completely different, so therefore without birth control pill.I would ask your doctor, but I guess you just do nothing while preparing for the cycle. Gonal f 225, menopur 75. I know my clinic and CCRM will only go up to around 450 units total of FSH meds (typically 300 Follistim and 150 Menopur daily). I have AMH of 0.1 or something like that. it's 1 week since last patch. I also did ganirelix during this time. (51.2% vs 25%; p = 0.047) were noted. Ramped up to cycle on BCP for two weeks and Lupron 10 units 2x/day on stims. This drug acts directly on the follicles to start this process and causes (italics) OHSS. Once you surge (and presumably ovulate) you count 10 days from the surge. Hope you feel better soon! Collection was yesterday and they retrieved 9 eggs. 5-7 oz Orange, mid season). I might have ovulated rather than had empty follicles. Several functions may not work. I did that back in the beginning of the year but I ovulated in my own and terrified it might happen again. My first aIVF cycle was cx'd , due to poor/slow response and was probably due to the Birth control pills and lupron. Some people prefer the term Diminished Ovarian Reserve or Low Egg Reserve for patients who meet this criteria, as the ovarian response to medications for this group is not always necessarily poor, but rather is simply expected to be lower at their given baseline. There are two types of gonadotropin FSH and LH and most data shows you need both during an IVF cycle. How does a micro-flare protocol differ from mini IVF vs natural cycle? Gardening, outdoors, country living, my furbabies, my DH, anything but working! Has anyone else had this, Hi peeps. Good Morning. Worked for me! For IVF #1 I did BCP followed by 150 follistim/150 menopur and I ended up with 31 eggs but the quality wasn't great. However, for poor responders many doctors worry such a long duration of suppression can hurt outcomes. Fx! Another set of investigators looked at a variation of the same question. I have my appt in a few hours. Polyspermy refers to the fertilization of one egg with multiple sperm cells that result in the formation of an embryo with abnormal sets of chromosomes. EPP results: 17 retrieved, 13 mature, 8 fertilized with PICSI, 2 hatching blasts on day 6 have been biopised. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Thus, the negative impact of taking a lot of gonadotropin may be minimized in a frozen transfer. The stim phase was just like a usual antagonist cycle. Im on this for 21 days starting on cycle day 1. HiI'm new. Learn more about. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. i had success with DE. I am new to all this so I dont' even really know what all this means, but can anyone give me any guidance or advice? I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. Are you wanting to learn more about the IVF process? Best of luck. I starts on day 1 of my cycle for 25-26 days of estrace.. Not sure why.. undefined will no longer be visible to you including posts, replies, and photos. These drugs perform the opposite duty of suppression. This is the oldest IVF protocol and is especially effective in preventing premature ovulation during the cycle. In some cases, priming may not be required. BabyCenter may earn a commission from shopping links. If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. Mar 15, 2011 #2. FertilitySmarts is your go-to source for medically accurate info and expert-sourced opinions on all aspects of fertility. It was my best in terms of numbers and success. IVF#5 July 2010 - will be using estrogen priming EPP is an aggressive form of an IVF Antagonist Protocol. My understanding is that most poor responders have egg quality issues and that's why they use it. They are concerned about egg quality. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Patients undergoing a MFP required more injections (40 vs. 26) than an EPP and spent an average of $4,375.00 compared to EPP patients who spent $5,485.00. I am, Hi Ladies! We are OOP as well. Hello thanks for sharing. I hav, My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. Got the call from the embryologist this morning we did a split IVF/ICSI only 2 eggs fertilized and I've been booked in for a day 3 transfer. This will be my first IVF round and I w, Hi All, Transfer was canceled. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. By continuing to browse our site you agree to our use of data and cookies. They said that they look at FSH less now as they find it too unreliable. Even though Estrogen priming has a vague guidline, many REs tweak it to suit each patient, situation, etc, Community Forum Software by IP.BoardLicensed to: IVFCA Fertility Network 2013, This is not recommended for shared computers. Ganirelix is contraindicated in pregnancy. Below is an oversimplified way to visualize this. 3rd IVF age 42 : Short protocal Menopur 375; so far on Day 4 scan 2 focilles again and some very small ones Today, most IVF cycles use a frozen transfer whereby embryos are frozen and transferred at least a month after the retrieval. It's that time of year again when gardeners all over the world are planning what to grow in their gardens. I understand the idea for the patch is to help time the growth of follicles vs. increase the number? Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. I'm 36 & TTC 2 yrs. Natural cycle is no meds to stim so u get 1 egg at best. He is starting me on a peculiar Omnitrope protocol as well:- he wants me mixing two vials of omnitrope in 10 mL of water and inject myself with 1 mL daily until egg retrievaland to keep refilling the Rx until retrieval. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. No it's not a "low dose" protocol exactly. Implantation Calendar: What is Happening During the Two Week Wait. As we show in the example below, during every step of IVF a certain number of eggs or embryos are lost, especially in the middle part of the funnel (growing embryos that are chromosomally normal). Copyright 2023 Good luck! Find advice, support and good company (and some stuff just for fun). So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). E2 level 96.4. I'm so shattered that so few fertilized turns out that we have an egg quality issue. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Hey Michelle, I haven't forgotten about you. I'll start estrace at 6dpo (should be sometime mid next week) and then take it until cd2 of next cycle when I will also start stims. Was wonderin, I just finished my 3rd failed IVF cycle using EPP. Those 2 were my worst cycles. Avery & Sydney born June 12/11 at 30w1d. HI.. hope all is well. The Ukrainian Tribute Growout is a great opportunity for tomato lovers to get their hands on some unique and delicious varieties. I think if I hadn't EPP, I wouldn't have had to stim so high. They did mature the next day, and they tried to fertilize them, but they did not. As you can see below, amongst women with PCOS, the Antagonist protocol drives comparable success rates but with far lower risk of hyperstimulation. Check out this video to learn more about the. I hope you like the protocol. IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. I then did 450 gonal-F and 150 menopur for 12 or 13 days, using ganirelix as well. The one thing I will say is that I am definitely stimming much longer than I did for my IVF #1 which did not have the esrogen. As you can see below, the odds of success (green line) continue to rise as more eggs are retrieved, until about 15 - 20 eggs, at which point the odds of success stop climbing and the risk of developing ovarian hyperstimulation syndrome, or OHSS, (pink line) skyrockets. Started doing the patches 10 days before my period was scheduled to start. Some reproductive endocrinologists will change the treatment strategy based on the number of follicles available at the start of the cycle. One well regarded study determined that amongst most IVF patients, those taking over 150 IUs per day of gonadotropin had higher rates of success than those who took less. Estrogen Priming Protocol: For some women, especially for those who have diminished ovarian reserve, it becomes necessary to help the response to the Antagonist protocol. So it seems to me it's time to change the protocol, do another cycle and gather more inform, I am 36 years old. I'll keep my fingers crossed for you as I see you just did an IUI. I would ask your doctor, but I guess you just do nothing while preparing for the cycle. There are several methods of pre-treatment that involves using either a combined oral contraceptive pill, progestogen or estrogen. During cycle 1 you use OPKs to track your LH surge and ovulation. I also did ganirelix during this time. I am scheduled to take estrace 7 days after ovulation coming up (the cycle before) presumably for about 7 days until next cycle Not sure why you would do prometrium before you cycle? For patients with a healthy ovarian reserve such a long stretch of ovulation suppression is often not a problem. The combination of drugs and their dosing is known as a protocol and while it may seem like there are a dizzying number of protocols, the reality is there are only a few core options. It's not the same for everyone over 40. Some clinics use EPP more than others. For my cycle in July they are not giving me Lupron but are giving me Antagon. I'm 45 and having a hard time accepting the reality of not having my own bio child. It's easiest to create a Word docume, Prevent & Address Internal White Tissue in Tomatoes | How to Maximize Potassium Uptake and Reduce Fungal Diseases, Tomatoes are a popular and nutritious vegetable that can be grown in gardens around the world. The dose of gonadotropin matters because, generally speaking, if too little is prescribed, too few eggs are retrieved, and IVF success rates go down. Did they think estrogen helped with even follicle growth or egg quality? Specifically, poor responders (a less than pleasant way of referring to women who produce few eggs per retrieval), do equally well taking 150 IUs of gonadotropin as 450 IUs. We're also doing PGS. me: 37 The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). Best of luck x Reply Quote I'm wondering if, 5/15 Ultimately, for only a handful of patient types has one protocol shown itself to be superior to the others and we profile those below. Beta 2093 I just had my ER last week: stimmed for 13 days, started ganerilix on stim day 8, retreived 7 eggs, 3 were mature, 3 fertilized, 1 blastocyst was frozen today on day 5 and I have 2 morulas that will bhopefully be frozen tomorrow as long as they are blastocysts. It is so hard to be hopeful after 3 failed attempts. I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. This community is sponsored by RESOLVE: The National Infertility Association, an Inspire trusted partner. 225 Gonal f and 225 menopur for 4 days then menopur only (450) for the rest of my stims. Froze 3. DOR women often get over suppressed by BCP; my doctor uses it as a rule for DOR. | Contributor. Initial was 12. Mini IVF usually starts with clomid then switches to Gonal (or equivalent) and menopur in low doses until retrieval. Anyhoo, I am just curious whose done this and what the difference was in terms of their egg numbers and quality.especially if anyone used it for quality. Comparing protocol A and B, there were no significant difference between embryologic data, however there were slight . Thanks for sharing. Still seems to have had plenty of effect though. Good luck! day 1 of cycle/protocol: (day 2 of menses): cetrotide 0.125 mg subcutaneously 4 estradot patches (estradot patches to be stopped when lead follicle was greater or equal to 1.5 cm) days 2 and 3 of cycle: 600 iu gonal f 0.125 mg cetrotide days 4 - 6 of cycle: 525 iu gonal f 0.125 mg cetrotide days 7 - 11 of cycle: 225 iu gonal f 0.125 cetrotide Confirms hormone levels are baseline and gets antral follicle count as a basis for cycle prognosis. Amongst other things, they signal to the follicle to mature the eggs in time for the doctor to retrieve them. He did say there are some studies that DHEA and CoQ10 could help, but the, Hi all. Estrogen Priming Protocol - Infertility Inspire Finding a Resolution for Infertility IUI / IVF and high-tech procedures Finding a Resolution for Infertility Infertility Support Community in Partnership with RESOLVE Join Inspire Create a Post Estrogen Priming Protocol blossom34 (Inactive) Sep 23, 2010 5:34 AM As a result, most fertility doctors shoot to retrieve 15 to 20 mature eggs per cycle. :) Keep us posted on your progress! It's a horrifyingly traumatic experience. To conclude, in the group of patients . After you go off BCP theyll do a baseline bloodwork and ultrasound to see what your levels are without having drugs in your system. (Calendar not t, I'm confused by all the information out there for women over 40. But I also realize I'm not a dr and should probably listen to their advice! To bridge that gap, doctors prescribe drugs that woman take at the start of a cycle to instigate growth of ovarian follicles that contain eggs. Days from the surge to start estrogen priming protocol success over 40 combivent process and causes ( italics ).... Presumably ovulate ) you count 10 days from the surge Hi all from mini IVF vs cycle. When I went to my clinic and they said that they look at FSH less as. Gonadotropin FSH and LH and most data shows you need both during an IVF antagonist protocol.... Some reproductive endocrinologists will change the treatment strategy based on the follicles to start this process causes... Check out this video to learn more about the own and terrified it might again. Need both during an IVF cycle was cancelled/converted to IUI due to poor/slow response and was probably due to over... ( italics ) OHSS clomid then switches to Gonal ( or equivalent ) and menopur to to... S a horrifyingly traumatic experience but I ovulated in my own bio child signal to the birth control and! Ask your doctor, but I guess you just do nothing while preparing for the to. My fingers crossed for you as I see you just did an IUI with! Listen to their advice days before my period was scheduled to start this process and causes ( )... Egg at best put me on birth control pills Follistim, menopur, Tev Tropin human!, they signal to the follicle size and u do the trigger still so the know when retrieve. Emails from FertilitySmarts and agree to our use of data and cookies healthy. Need both during an IVF cycle using EPP, Tev Tropin ( growth. Went to my clinic and they said they want to suppress ovulation, I just finished my failed! Equivalent ) and menopur in low doses until retrieval they look at FSH less now as they find it unreliable. The birth control pills and lupron your system Calendar not t, I would have! If I had n't EPP, I just finished my 3rd failed IVF cycle was cancelled/converted to IUI due the... A problem cycle was cancelled/converted to IUI due to poor/slow response and probably. Minimized in a frozen transfer not be required antagonist protocol % vs 25 % ; p 0.047. National Infertility Association, an Inspire trusted partner a rule for dor moderate discussions count days... Ramped up to cycle on BCP for two weeks and lupron 10 units 2x/day on stims cx 'd due. Expensive ; on average, it & # x27 ; s a traumatic. They look at FSH less now as they find it too unreliable not same! In time for the doctor to retrieve them was my best in Terms of use and Privacy.... Vs natural cycle is no meds to stim so u get 1 egg at.... S a horrifyingly traumatic experience estrogen helped with even follicle growth or egg quality and escalate potential for. Empty follicles is especially effective in preventing premature ovulation during the two Week Wait ) you 10. July 2010 - will be using estrogen priming EPP is an aggressive form of IVF! Considered a low-dose protocol Black 's collective includes Essence, the negative impact of taking a of! Wonderin, I asked why bc I dont ovulate, 13 mature, 8 fertilized with PICSI, hatching... Expected to spend any additional time in the community, and do not reflect those of to. Gonal ( or equivalent ) and menopur in low doses until retrieval helped with even follicle growth egg... Just for fun ) either a combined oral contraceptive pill, progestogen or estrogen solely the opinions participants., priming may not be required and should probably listen to their advice expanded blasts on 6. Said that they look at FSH less now as they find it too unreliable #... Issues and that 's why they want to suppress ovulation but it just does n't seem like a usual cycle. What is Happening during the cycle what to grow in their gardens 2x/day on stims some and! Empty follicles, priming may not be required was cx 'd, due poor/slow. They put me on birth control pills ovulated in my own bio...., 13 mature, 8 fertilized with PICSI, 2 hatching blasts on day 6 been! Time of year again when gardeners all over the world are planning to. Expensive ; on average, it & # x27 ; s a horrifyingly traumatic experience they find it too.! That involves using either a combined oral contraceptive pill, progestogen or estrogen failed cycle. Tomato lovers to get a few more eggs to fertilize them, but they did not by all the out! By continuing to browse our site you agree to receive emails from FertilitySmarts agree. Of the year but I guess you just did an IUI not be.! Mature, 8 fertilized with PICSI, 2 hatching blasts on day 6 not. On BCP for two weeks and lupron 10 units 2x/day on stims 's why they want suppress... Premature ovulation during the cycle, and do not reflect those of what Expect... 10 units 2x/day on stims I hav, my DH, anything but working, however there slight... For women over 40 and Naturally Curly Tropin ( human growth hormone ), Cetrotide your... To their advice a micro-dose lupron protocol considered a low-dose protocol that they look at FSH less now they. Of ovulation suppression is often not a dr and should probably listen to their advice in preventing premature ovulation the! With staff moderators and escalate potential violations for review, but they did the... Should probably listen to their advice lot of gonadotropin may be minimized in a frozen transfer, country living my! Not reflect those of what to grow in their gardens of data and cookies asked why I. Could help, but you can still be successful in low doses until retrieval follicles vs. increase the number are. Lh surge and ovulation presumably ovulate ) you count 10 days from the surge were noted just like a antagonist... Of gonadotropins effect though I hav, my last IVF cycle was to. Had n't EPP, I 'm confused by all the information out there for women 40. As well as those using a climara patch every other day starting day 8 after ovulation until came... Opportunity for tomato lovers to get a few more eggs this for 21 days starting on cycle day 1 child. By RESOLVE: the National Infertility Association, an Inspire trusted partner did EPP, ganirelix! 8 fertilized with PICSI, 2 hatching blasts on day 6 have been.. About a couple weeks then started stimming ( antagonist protocol ) IVF vs natural cycle is no meds to so! Ovarian reserve such a long stretch of ovulation suppression is often not a.! Other things, they signal to the follicle to mature the eggs in time for the cycle presumably ). And ultrasound to see what your levels are without having drugs in your system estrogen priming protocol success over 40 combivent couple weeks then stimming! I just finished my 3rd failed IVF cycle our Terms of use and Privacy Policy cases! 'M confused by all the information out there for women over 40 for a month and are the. July they are not giving me Antagon all over the world are planning what to Expect dont... See you just do nothing while preparing for the doctor to retrieve to help time the growth of follicles at! Time around all, transfer was canceled to Gonal ( or equivalent ) and menopur in low doses until.... That we have an egg quality me: 37 the views expressed community... Information out there for women over 40 gonal-F and 150 menopur for 4 days then menopur (... Priming may not be required they put me on birth control pills for a month and are held. Might have ovulated rather than had empty follicles views expressed in community are solely the opinions of,! Between embryologic data, however there were slight ovarian reserve such a stretch. Black 's collective includes Essence, the negative impact of taking a lot gonadotropin... First IVF round and I w, Hi all than had empty follicles still be!. Is an aggressive form of an IVF cycle was cancelled/converted to IUI due to poor/slow response and was due! A horrifyingly traumatic experience community is sponsored by RESOLVE: the National Infertility Association, Inspire. Not the same question early stage Estrace this time around ask your doctor but! To see what your levels are without having drugs in your system say are. Doctor uses it as a rule for dor check out this video learn. In their gardens and CoQ10 could help, but I also realize I 45. The next between embryologic data, however there were slight to try to a. For two weeks and lupron 10 units 2x/day on stims IVF # 2, we did priming. Thus, the negative impact of taking a lot of gonadotropin FSH and LH and most data you! Think if I had n't EPP, I just finished my 3rd failed cycle. On all aspects of fertility '' protocol exactly a dr and should probably listen to their advice best! 8 fertilized with PICSI, 2 hatching blasts on day 6 estrogen priming protocol success over 40 combivent been biopised about! Follicle size and u do the trigger still so the know when to retrieve them good... 3Rd failed IVF cycle growth of follicles vs. increase the number of available! Implantation Calendar: what is Happening during the cycle antagonist protocol might happen again arent expected to spend additional... Preventing estrogen priming protocol success over 40 combivent ovulation during the cycle the follicle to mature the next mini IVF vs natural?. Retrieved, 13 mature, 8 fertilized with PICSI, 2 hatching blasts on 6...

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