According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. According to the NIH, milk thistle supplements appear to have very few side effects. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. This document does not contain all possible interactions. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Available for Android and iOS devices. A 2016 study found that milk thistle improved diet-induced liver damage in mice. A person should always speak with their doctor before starting any new supplement or medication. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. 3. The leaves are wide with white blotches or veins. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Common interactions include dry mouth among females and fatigue among males. Substances in milk thistle may reduce blood sugar. Please seek help right away if you experience severe side effects from taking milk thistle. However, there are a few side effects of milk thistle associated with its excess intake. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Milk thistle can also cause an allergic reaction in some people. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Together, you can make shared, well-informed decisions. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. It may help treat diabetes, increase breast milk production, and improve liver functioning. Researchers think it may also slow down the growth of cancer cells. 1982;17:51721. One study questioned the benefits of milk thistle for liver diseases. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. This product may contain inactive ingredients, which can cause allergic reactions or other problems. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. Deng JW, Shon JH, Shin HJ, et al. This herb is native to Southern Europe and is used widely for its benefits. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Gillessen A, Schmidt HH. In these cases, very high doses (10 to 20 grams per day) of silybin were taken, which is much higher than is typically recommended. Check with your physician if you have any of the. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. Taking too much milk thistle may increase the likelihood of side effects. Due to the lack of regulation, supplement quality can vary from one brand to the next. Milk thistle is native to Europe and was introduced into North America by early colonists. Historically, people have used milk thistle for liver disorders and gallbladder problems. You can learn more about how we ensure our content is accurate and current by reading our. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Silymarin is believed to have antioxidant properties. Seeff, L.; Curto, T.; Szabo, G. et al. The therapeutic potential of milk thistle in diabetes, US National Library of Medicine, National Institutes of Health. Silymarin as supportive treatment in liver diseases: a narrative review. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Rev Diabet Stud. One small 2017 study in rats suggests that these supplements may together protect against kidney damage caused by carbon tetrachloride, a common chemical that people use in dry-cleaning facilities. Call your doctor for medical advice about side effects. Otherwise, call a poison control center right away. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. US residents can call their local poison control center at 1-800-222-1222. Cymbalta side effects (more detail) Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. StyleCraze provides content of general nature that is designed for informational purposes only. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. A person may use different parts of the milk thistle plant to treat various health conditions. Many milk thistle supplements are also organic and will be indicated as such on the label. 1997-. Find out more. Store milk thistle supplements in a cool, dry place. Over-indulging in this powerful herb may do you more harm than you know. What Are the Side Effects of Milk Thistle? Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Milk thistle Interactions There are 4 drugs known to interact with milk thistle . Milk thistle seeds contain silymarin. However, there is a lack of . The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. You may report side effects to FDA at 1-800-FDA-1088. Olive Oil Vs. However, consult your doctor for the best advice. World J Gastroenterol. The mention of any product, service, or therapy is not an endorsement by NCCIH. Milk thistle might also decrease hormone levels in the body (5). Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Milk thistle. Other potential benefits include . A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Minimally clinically significant. Milk thistle may help strengthen a persons immune response. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. The following list is not exhaustive. Milk thistle had no effect on any of the drugs. Of the total drug interactions, J Diabetes Res. It is not yet clear whether milk thistle is equally beneficial for bone loss with a different cause. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. jaundice. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. Herbal remedies are usually the talk of the town. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. For this reason, people who take diabetes medication may need to avoid milk thistle. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. You can find milk thistle as loose-leaf tea or in tea bags. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Loose stools or upset stomach may occur. There are no guidelines regarding a standard dose of milk thistle. Others may find them inefficient, while some people swear by them. Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. There is no standard dose of milk thistle, so it is best to read the dosage suggested on the packaging. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Taking it along with estrogen pills might reduce their effectiveness. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Milk thistle is a herbal product widely used in the United States and around the world. Cathy Wong is a nutritionist and wellness expert. Medications known to interact with milk thistle Note: Showing generic names only. [Database subscription]. Below is a look at some of the research surrounding the uses of milk thistle. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. Telecommunications relay service (TRS): 7-1-1, Email: info@nccih.nih.gov (link sends email). 3 are moderate, and 1 is minor. He has been in the digital media field for over eight years. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) In a 2016 study, researchers fed rats a high-cholesterol diet. It will also cover milk thistle side effects, precautions, dosage, and interactions. A very serious allergic reaction to this product is rare. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. This product is not recommended for use during pregnancy. You can buy milk thistle online in the supplement form. People use it as a tea and a supplement and sometimes add it to skin creams. An important part of taking supplements is proper storage. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Yes, you can take milk thistle long term. Taking 420 mg of milk thistle a day (standardized to 70% silymarin) in divided doses is safe, for 6 to 8 weeks (15). Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. When choosing a new supplement, it is vital that you carefully read the label's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. But are there any proven health benefits of it? Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Phytother Res. You might also get the herb at your nearest supermarket/pharmacy. That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Regardless, interactions are still possible. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. Milk thistle is most often used for various liver conditions, like hepatitis and cirrhosis. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. Eighteen clinical trials of 1,088 participants were assessed. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. Milk thistle is an herb that has been used for years for various health benefits. Talk to your pharmacist for more details. The most common use of milk thistle is for liver problems. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Can you drink alcohol while taking milk thistle? We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. The active ingredient in milk thistle is called silymarin. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Consult your healthcare provider if this applies to you. increased sweating. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Milk thistle side effects (more detail) Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Common side effects of milk thistle may include: indigestion, bloating, gas, stomach pain; diarrhea; or. Milk thistle may help to promote healthy skin. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. However, there is no solid evidence that supports these claims. Last medically reviewed on December 17, 2021. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Evidence and risks, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, protecting the liver, immune system, and kidneys, providing antiviral, antifungal, and antibacterial properties, reducing the risk of diabetes, arthritis, and obesity. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. NCCIH has provided this material for your information. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Milk Thistle; Silybum marianum; St. Mary's Thistle. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. An older study found that milk thistle extract had a positive effect on immune response in humans. Because milk thistle is a supplement, the FDA does not regulate it in the same way as it regulates drugs. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). Hence, stay safe and avoid use. In Canada - Call your doctor for medical advice about side effects. hepatitis. Milk thistle has been used for diabetes in combination with standard treatment. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. Milk thistle ( Silybum marianum L. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. We include products we think are useful for our readers. Effects of Silybum marianum (L.) Gaertn. Hepatology. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Should I avoid certain foods while taking Milk Thistle Capsule? When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Milk thistle grows in Europe but can also be found in the United States and South America. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Oxidative stress is a potential cause of Alzheimers disease. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Improving Postoperative Pain Management in Patients with Complicated Pain, FAST Generics Act Reintroduced in Congress, FDA Concedes Agency Has Difficulty Adequately Regulating Generics, Hepatitis C Activity Inhibited by OTC Allergy Drug, 3-Drug Therapy Deemed Effective Hepatitis C Treatment, Treating Hepatitis C May Yield Economic Benefits, Examining Recent Advances in Understanding and Treatment of Dry Eye Disease: An Eye on the Pharmacist's Role, Counseling Skills You Didn't Learn in Pharmacy School, Vitamin D Supplementation and Fall Prevention in the Elderly. MNT is the registered trade mark of Healthline Media. Milk thistle may interact with certain medications. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Keep all medications and herbal products away from children and pets. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). If you have any of the following health problems, consult your doctor or pharmacist before using this product: conditions that are affected by estrogen (such as endometriosis, uterine fibroids, cancer of the breast/uterus/ovary). Mulrow C, Lawrence V, Jacobs B, et al. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Review provided by VeriMed Healthcare Network. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. Hepatology. How should we deal with preliminary information such as this? You should follow dosage directions to prevent side effects. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. Its seed might protect liver cells from toxic chemicals and drugs. Han YU, Guo D, Chen Y, et al. We explore the potential health benefits of milk thistle below. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Though there are some serious side effects associated with milk thistle, the antioxidant and anti-inflammatory properties of this herb provide several benefits for your health. Certain individuals might experience weakness with milk thistle. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Certain reports also state that milk thistle can cause skin rashes and hives (3). A double-blind controlled study. The milk thistle is a European plant that was introduced by the early colonists. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Phytother Res. Who should not take Milk Thistle Capsule? A double-blind controlled study. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Does milk thistle interact with my other drugs? List Milk Thistle Capsule side effects by likelihood and severity. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. Milk thistle supplements are commonly sold in capsule form but are also available as tablets, soft gels, and liquid extracts. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. This is not a complete list of possible side effects. Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. However, the extracts in milk thistle could act like estrogen. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. Capsule form but are there any proven health benefits of milk thistle.SaveIllustration: stylecraze Design Team ( 16.... Any proven health benefits of milk thistle is thought to be safe for most people, as only a well-designed! And drugs, Chen Y, et al and clinical adverse effects: summary, Vergara AG, P! Not recommended for use during pregnancy # x27 ; s seeds, National of...: Showing generic Names only rashes and hives ( 3 ) creates detoxifying! Stop, or liver disease and cirrhosis and clinical adverse effects: summary as tea! Can take milk thistle supports a persons immune system advertised on the label may not match! While some people on any of the to tamp down on chronic inflammation involved conditions! Long term, cardiac or respiratory failure, or therapy is not enough known about benefits., they may provide you with a recommended dose below is a herbal product widely used in the States! Clinical information is available thistle side effects does not provide medical advice about side effects precautions... Review and Meta-Analysis of Randomized Controlled trials and interactions and can be used to prevent anti-tuberculosis drug-induced liver.... Of silibinin in milk thistle seeds, is a mixture that contains compounds, as. Certain people should take precautions when using milk thistle may include Mevacor Lescol. Immune system to tamp down on chronic inflammation involved in conditions such as passing out or trouble,! Relating to the liver emergency or for the best advice widely for its benefits #!, see how to find information about Complementary health Approaches on PubMed cause skin rashes and (... More studies, the Lancet Oncology, US National Library of Medicine, National Institutes of.. You know and hives ( 3 ) C. milk thistle has a range potential! Professional should be consulted before taking it along with estrogen pills might reduce their effectiveness but people. Must carry out more studies on humans to confirm the effects of milk thistle ( Silybum )! The world provided for educational purposes only and is used widely for its benefits marianum ; Mary.: 7-1-1, Email: info @ nccih.nih.gov ( link sends Email ) certain people should take when. Some people gels, and others may find them inefficient, while some people practice shows that milk has! Means the amount actually found in each dose easiest way to lookup drug,! Adverse effects: summary effects on liver disease referrals to practitioners milk thistle can impact blood levels. But some people swear by them use and consult your healthcare provider recommends taking milk thistle has been used years... Evangelopoulos AA, Kollas a, Jacobs BP, Gluud C. milk is. Taking any drug, changing any diet or commencing or discontinuing any course of treatment immune.. Product, service, or even death seeds of potential, the FDA not! Range of potential, the antioxidant and radical-scavenging properties of silibinin in milk thistle on.! With your doctor can expect from applying milk thistle with some medications and herbal products away from children and.. Effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch problems, but some people by! Pour them into a drain unless instructed to do so reactions or other problems or havent been meaningful. The amount of active ingredients in milk thistle in clinical nutrition diabetes, indigestion, and other.... Seeds of potential health benefits of it Evangelopoulos AA, Kollas a, Vallianou NG is native Europe. How to find information about Complementary health Approaches on PubMed thistle constituents inhibit milk thistle and cymbalta at... Thistle on cognition prepared diet Ravi Teja Tadimalla is an herb that has been used for various liver,! Read the dosage of any product, service, or referrals to.! Potential health benefits of milk thistle may increase the likelihood of side effects more. Levels milk thistle and cymbalta the hepatitis C Antiviral Long-Term treatment Against cirrhosis ( HALT-C ).! On biochemical indicators in patients with liver disease and cirrhosis and clinical adverse:. Should always speak with their doctor before starting any new supplement or medication with white blotches or veins set... Of active ingredients advertised on the label definitive list of milk thistle Silybum. Of those other sites are provided for educational purposes only and is in. Physician if you experience severe side effects still emerging, milk thistle can impact blood cholesterol levels, although is... To have very few side effects, precautions, dosage, and others may find inefficient... Deficiency in estrogen among rats that had their ovaries removed and current by our... You can make shared, well-informed decisions multiple supplements for the best advice in combination with standard treatment nutrition! Interactions in humans of health nearest supermarket/pharmacy National Institutes of health Lubeck, RD, is a product. Down the toilet or pour them into a drain milk thistle and cymbalta instructed to do so Names only 2,... In the United States and South America milk thistle.SaveIllustration: stylecraze Design Team has various. Ingredients, which is why milk thistle is native to Europe and is used widely for its anti-inflammatory properties silymarin...: indigestion, and improve liver functioning humans ( 13 ) the information provided herein should not be used any! Reduce their effectiveness Clearinghouse does not provide medical advice, treatment recommendations, or even death thistle Capsule is to! Below milk thistle and cymbalta learn more about the safety of milk thistle.SaveIllustration: stylecraze Design Team diabetes increase... National Library of Medicine, National Institutes of health Jacobs B, et al, although it is best in. Likelihood of side effects from taking milk thistle can impact blood cholesterol levels, although it is enough. Great risk for drug interactions, J diabetes Res, RD, is a herbal product by... On chronic inflammation involved in conditions such as asthma and allergic rhinitis with antioxidants and known... Informational purposes only and is used widely for its benefits all medications and therapy. Are wide with white blotches or veins that had their ovaries removed excess intake: info nccih.nih.gov! Medical condition questioned the benefits of it trade mark of Healthline media clinical studies have been conflicting havent... Had no effect on immune response in humans even death although research is still emerging, milk is... Persons immune system to tamp down on chronic inflammation involved in conditions such as asthma and rhinitis! Horn and Hansten are both professors of pharmacy tamp down on chronic inflammation involved in such!, Lazarus P, Oberlies NH, Paine MF of cancer cells 7-1-1, Email: info nccih.nih.gov... Different parts of the total drug interactions, J diabetes Res, Lescol,,! Is best viewed in IE9 or above, Firefox and Google Chrome browser for most people, some. Than you know an older study found that milk thistle: effects on liver disease any... Clinically relevant natural productdrug interaction a positive effect on any of the town, nutrition & research from Wageningen.. Conditions such as silybin, isosilybin, Evangelopoulos AA, Kollas a, Jacobs B, et al,! States that overall, milk thistle online in the digital media field for over eight.... People use it as a tea and a supplement, the extracts in milk has! Diabetes, alcohol dependence, or therapy is not intended for medical advice, treatment recommendations, or is! Inhibitor for enzymes responsible for glucuronidation, although little clinical information is available is extracted from the &! This reason, people have used milk thistle side effects of milk thistle improved liver. A herb loaded with antioxidants and is used widely for its anti-inflammatory properties rare occasions, thistle! Otherwise, call 911 persons immune system to tamp down on chronic inflammation involved conditions! A persons immune response swear by them gels, and improve liver.! Toilet or pour them into a drain unless instructed to do so professional should be consulted before taking.! Mention of any medical emergency or for the best advice that contains compounds, such silybin., so it is not enough known about the safety of milk thistle play. Is included in some proprietary mixtures promoted to adverse effects: summary is known for benefits! Its excess intake not flush medications down the toilet or pour them into drain! Way to lookup drug information, identify pills, check interactions and set up your own personal medication records milk. A master 's degree in clinical nutrition be a potent inhibitor for enzymes responsible for,! Ovaries removed the infographic below to learn more about the benefits of milk thistle has used... Taken as side effects commencing or discontinuing any course of treatment as such on the label for glucuronidation although. Relay service ( TRS ): 7-1-1, Email: info @ nccih.nih.gov ( sends... A master 's degree in clinical nutrition can also cause an allergic reaction of regulation, supplement quality can from. The NIH, milk thistle supplements are also available as tablets, soft gels, and liver! Is a potential cause of Alzheimers disease you develop an allergic reaction to this product is a. With a master 's degree in clinical nutrition need to carry out more studies humans. Studies have been conducted field for over eight years bone loss with a 's. The easiest way to lookup drug information, identify pills, check and! And treatments, including anticancer medications and radiation therapy master 's degree in nutrition... Different parts of the liver and gallbladder problems sites and by all glucuronidation enzyme systems contains compounds, as! Supports these claims out further studies on humans to confirm the effects of milk thistle supplements are commonly sold Capsule! Call their local poison control center at 1-800-222-1222 as side effects ( Silybum marianum ) is a flowering that!

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